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A Molecule Away from Madness: Tales of the Hijacked Brain

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Longlisted for the PEN/E.O. Wilson Literary Science Writing Award

Riveting stories of the brain on the brink, from an acclaimed cognitive neurologist.

Our brains are the most complex machines known to humankind, but they have an Achilles heel: the very molecules that allow us to exist can also sabotage our minds. Here are gripping accounts of unruly molecules and the diseases that form in their wake.

A college student cannot remember if she has eaten breakfast. By dinner, she is strapped to a hospital bed, convinced she is battling zombies. A man planning to propose marriage instead becomes violently enraged, gripped by body spasms so severe that he nearly bites off his own tongue. One after another, poor farmers in South Carolina drop dead from a mysterious epidemic of dementia.

With an intoxicating blend of history and intrigue, Sara Manning Peskin invites readers to play medical detective, tracing each diagnosis from the patient to an ailing nervous system. Along the way, Peskin entertains with tales of the sometimes outlandish, often criticized, and forever devoted scientists who discovered it all.

Peskin never loses sight of the human impact of these conditions. Alzheimer’s Disease is more than the gradual loss of a loved one; it can be a family’s multigenerational curse. The proteins that abound in every cell of our bodies are not simply strings of oxygen, hydrogen, nitrogen, and carbon; they are the building blocks of our personalities and relationships. A Molecule Away from Madness is an unputdownable journey into the deepest mysteries of our brains.

ISBN-13: 9781324050544

Media Type: Paperback

Publisher: Norton W. W. & Company Inc.

Publication Date: 02-07-2023

Pages: 224

Product Dimensions: 5.30(w) x 8.10(h) x 0.60(d)

Sara Manning Peskin is an assistant professor of clinical neurology at the University of Pennsylvania. Her writing has appeared in the New York Times, Boston Globe Magazine, and the Philadelphia Inquirer. She lives in Philadelphia, Pennsylvania.

Table of Contents

Introduction 1

Part 1 DNA Mutants 9

Chapter 1 In Suspension 17

Chapter 2 La Bobera de la Familia 32

Chapter 3 Has Anyone Seen My Father? 53

Part 2 Rebellious Proteins 69

Chapter 4 A Zombie Apocalypse 76

Chapter 5 The Muscle Man 91

Chapter 6 Deadly Laughter 105

Part 3 Brain Invaders and Evaders 127

Chapter 7 Like Lucifer 135

Chapter 8 An Honest Liar 147

Chapter 8 Filth Parties 161

Epilogue 180

Acknowledgments 185

Glossary 187

Notes 191

Index 207