The Woman Who Couldn't Wake Up: Hypersomnia and the Science of Sleepiness

Sleep was taking over Anna's life. Despite multiple alarm clocks and powerful stimulants, the young Atlanta lawyer could sleep for thirty or even fifty hours at a stretch. She stopped working and began losing weight because she couldn't stay awake long enough to eat. Anna's doctors didn't know how to help her until they tried an oddball drug, connected with a hunch that something produced by her body was putting her to sleep.

The Woman Who Couldn't Wake Up tells Anna's story--and the broader story of her diagnosis, idiopathic hypersomnia (IH), a shadowy sibling of narcolepsy that has emerged as a focus of sleep research and patient advocacy. Quinn Eastman explores the science around sleepiness, recounting how researchers have been searching for more than a century for the substances that tip the brain into slumber. He argues that investigation of IH could unlock new understandings of how sleep is regulated and controlled. Eastman foregrounds the experiences of people with IH, relating how publicity around Anna's successful treatment helped others form a community. He shows how a group of patients who felt neglected or dismissed united to steer research toward their little-known disorder.

Sharing emerging science and powerful stories, this book testifies to the significance of underrecognized diseases and sheds new light on how our brains function, day and night. It is essential reading for anyone interested in sleep and sleep disorders, including those affected by or seeking to treat them.

ISBN-13: 9780231194648

Media Type: Hardcover

Publisher: Columbia University Press

Publication Date: 08-01-2023

Pages: 320

Product Dimensions: 6.20(w) x 9.30(h) x 1.10(d)

Quinn Eastman is a technical editor at Emory University School of Medicine. He was trained as a biochemist, receiving a PhD from Yale University, and has worked as a journalist, covering local government and environmental issues as well as sleep research.

Table of Contents

Introduction
1. Anna Sleeps a Lot, and We Don’t Know Why
2. The Doctors and GABA
3. The Antidote
4. Rye Versus MSLT
5. Behind the Curtain
6. The Essence of Sleepiness
7. My Favorite Mistake
8. The Atlanta Sleepers Club
9. The Story of Flumazenil
10. Weird Drugs
11. The Heart of the Brain
12. Immobilized by Happiness
13. Frustrating and Mostly Fruitless
14. Everything Off Label
15. Knock Yourself Out
16. Biomarkers of Sleepiness—and IH
17. The FDA Opens a Door
Acknowledgments
Notes
Index Show More